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|GENEVA， Sept. 15 (Xinhua) -- The UN Special Envoy for Syria said Thursday that UN aid convoys had not yet reached civilians trapped in besieged and hard-to-reach locations in Syria despite a nationwide ceasefire holding since Sept. 12.
"The second dividend of the U.S. and Russian agreement was， and remains， humanitarian access. That is what makes a difference for the people apart from no more bombs or mortar shelling taking place，" Staffan de Mistura told the press.
"Are we disappointed? Of course we are， but who is particularly disappointed are the Syrian people，" he added.
While a ceasefire brokered by the United States and Russia last week after marathon discussions appears to be respected by factions at war since 2011， the diplomat said the Syrian government permits allowing humanitarian convoys to reach priority locations including east Aleppo had yet to be received.
A key point addressed by Washington and Moscow is how to manage the Castello Road， the only passage providing road access to east Aleppo where some 275，000 civilians are essentially trapped.
The plan， which remains too sensitive to make entirely public， is to disengage government troops and rebel forces and set up special status checkpoints along the road which runs through conflict lines.
This is hoped to give convoys the required security and clearance that has until now been lacking.
Damascus would be informed of relief operations through a UN monitoring mechanism， providing the officials with information of what goes into trucks and of subsequent deliveries.
For other locations including Kafraya， Foah， Madaya， Az-Zabadni and Madamiyet Elsham， de Mistura indicated that government authorisation was still mandatory.
"Can well fed， grown men please stop putting political， bureaucratic and procedural road blocks for brave humanitarian workers who are ready and willing to go to serve women， children， wounded civilians in besieged and cross-fire areas?" de Mistura's special advisor Jan Egeland questioned.
"If they do that， we are willing and able to go to all of these places in the next few days and we're very hopeful that we will indeed be able to do so，" he added.
Once humanitarian deliveries take place， and if the ceasefire holds， this should set in motion the third major component of the landmark agreement calling for military cooperation between the United States and Russia to target terrorist groups such as Nusra -- now known as Jabhat Fateh al-Sham -- and ISIS.
The practice of prescribing medication for periods of time or for conditions not FDA-approved is known as off-label use. Although the FDA regulates how a medication can be advertised or promoted by the manufacturer Air Max 90 Sale , these regulations do not restrict a doctor’s ability to prescribe the medication for different conditions, in different doses Air Max 95 Sale , or for different lengths of time.
For example the use of more than one weight-loss medication at a time (combined drug treatment) is an example of an off-label use.
When it come to losing weight, there are drugs that are recognized to lose a person a lot of weight but there are designed for other conditions. Doctors are known to use such drugs in safe doses for weight loss. Below we look at two such drugs.
The first is Buproprion. It is specifically approved as an anti-depressant drug. It is also approved as a smoking cessation drug. It is marketed as Wellbutrin the antidepressant and Zylon the smoking ceasation drug.
The drug is associated with clinically significant weight loss of about 5 pounds in 8 weeks. This has prompted it use as an off-label weight loss drug.
Bupropion weight loss like other approved weight loss medication like phentermine and sibutramine is also a central nervous system stimulant. It affects neurotransmitters in the brain inhibiting the feeling of hunger.
However unlike them Air Max 2018 Sale , it mainly affects a different set of neurotrnsmitters – dopamine and norepinephrine rather than serotonin.
Neurotransmitters are brain chemicals used to send messages with the central nervous system and the brain. They are released by nerve cells and stimulate reception on other cells. Once the message is sent, the neurotransmitters are destroyed or absorbed into the cell that produced them. This is technically referred to as neurotransmitters re-uptake. Bupropion affects dopamine and norepnehrine by inhibiting the re-uptake.
Inhibited re-uptake results to the message of the neurotransmitter to be sustained as well as amplified. Dopamine and norepinephrine tend to amplify and sustain the feeling of fullness or satiety.
The second major off-label weight loss medication is topiramate which was firstmarketed as Topamax. Topamax in itself is an anti-convulsant developed by Johnson and Johnson for the treatment of seizures disorders; mainly epilepsy.
Generic names include Topiramate while brand names include Epitomax.
During its clinical trials it was noticed that some participants lost weight without trying. Immediately Johnson and Johnson began trials for Topamax for weight loss. This was in 2002.
However the topamax weight loss trials were abandoned after users suffered negative side effects like tingling sensations Air Max Sale , fatigue, sleeplessness Nike Air Max 1 Mens Sale , memory problems etc.
Experts were not exactly sure on how topamax effected weight loss. But the people that took the medication described having fewer thoughts about food as well as having a sense of feeling full sooner.
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